Table 1.

Validated and putative target transcripts of miR-663 that link this microRNA with inflammatory, neurodegenerative and cardiovascular diseases, as well as with cancer.

Target Transcripts	MiR-663 Effects	References
Opposite effects on inflammation
JunB, JunD	Anti-inflammatory, through reducing AP-1 activity and miR-155 expression	[27]
TGFβ1	Worsens lupus erythematous development	[32]
APC	Pro-inflammatory through the activation of Wnt pathway	[33]
Stimulation of cell proliferation and migration
TGFβ1	Increases the survival of non-irradiated bystander cells	[37]
HSPG2	Increases chemoresistance of MDA-MB-231/ADM cell line	[47]
TGFβ1	Inhibits apoptosis induced by endoplasmic reticulum stress	[54]
TGFβ1, P53, Bax, Fas	Increases lung cancer cell proliferation	[57]
PUMA/BBC3, BTG2	Inhibits apoptosis and promotes tumor development	[59]
Inhibition of cell proliferation and migration
eEF1A2	Impairs the proliferation of MCF7 cells	[45]
CDKN2A	Promotes the proliferation of nasopharyngeal carcinoma C666-1 cells	[48]
p21(WAF1/CIP1)	Promotes the proliferation of nasopharyngeal carcinoma cells	[50]
TGFβ1	Antimetastatic in SW480 colorectal cancer cells	[28]
TGFβ1	Inhibits epithelium-to-mesenchyme transition of two thyroid carcinoma cell lines	[51]
MDGA1, FRAS1	decreases renal cancer cell proliferation and migration	[53]
eEF1A2	Inhibits proliferation and invasion of pancreatic cancer cells	[56]
Bcl-2	Implicated in waltonitone treatment-induced inhibition of lung cancer cell line proliferation	[60]
PI3KCD	Inhibits proliferation and invasiveness of glioblastoma cells	[61]
CXCR4	Increases survival of mice with glioblastoma	[62]
TGFβ1, MMP2, E-Cadherin	Inhibits proliferation and invasiveness of glioblastoma cells	[63]
H-ras	Inhibits proliferation of K-562 cells	[67]
UQCC2	Increases phosphorylative oxidations and decreases tumor development	[72]
Prevention of arterial injury
TGFβ1	Inhibits endothelial cell migration under high concentrations of uric acid	[76]
JUNB, MYH9	Inhibits vascular smooth muscular cell phenotypic switch	[77]