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. 2018 Sep 1;19(9):2599. doi: 10.3390/ijms19092599

Figure 3.

Figure 3

Proliferative activity of NSTS-47 cells after various experimental treatments. Proliferative activity was measured using an MTT assay after 6 days of incubation. The data represent the mean ± SD. Experiments were repeated three times in hexaplicate (A,D–H) or in triplicate (B,C). * p < 0.05 indicates a significant difference compared to control cells. (A) Sunitinib significantly decreased the proliferative activity of NSTS-47 cells. (B) NSTS-47 cells were sensitive to sunitinib, and this effect was not influenced by the presence of PDGF-BB at a high concentration (10 ng/mL). (C) Medium containing inhibitor and PDGF-BB was changed every 24 h during cultivation, which had no significant effect on the efficacy of the inhibitor. (D) NSTS-47 cells were also sensitive to erlotinib, as this inhibitor significantly affected cell proliferation. (E) No significant effect was observed after U0126 treatment. (F) FR180204 also did not significantly affect proliferative activity. (G) The combination of erlotinib and sunitinib significantly decreased the proliferative activity of NSTS-47 cells. (H) The combination of U0126 and FR180204 did not have a significant effect on NSTS-47 cell proliferation.