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. 2018 Aug 28;19(9):2548. doi: 10.3390/ijms19092548

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FGFR3 and TP53 mutation frequency and prognostic impact on tumor progression. (A) Oncoprint graph for FGFR3 and TP53 mutation analysis. (B–D) Kaplan–Meier survival curves display progression-free survival (PFS). (B) Survival curves of tumors with detected FGFR3 mutations (red curve, n = 30) compared to non-mutated FGFR3 gene status (blue curve, n = 34). (C) Kaplan–Meier analysis of tumors with mutated TP53 (red curve, n = 17) compared to wildtype TP53 (blue curve, n = 46). (D) Impact of double mutations on risk stratification of tumor progression is demonstrated. Univariate analysis of double mutations (red curve, n = 6) compared to all other combinations of mutated and non-mutated FGFR3 and TP53 genes (blue curve, n = 57). n, overall number of cases; events, overall events of tumor progression.