Table 7.

Bioactive effects of Aloe plant species: clinical studies.

Biological Activities	Observed Effects	Active Molecules	References
Wound healing and cell proliferation	Tyrosinase activity inhibition, re-epithelialization, wound healing promotion	Arbutin, aloesin	[310,311,312,313,314,315,316,317]
Anti-inflammatory and immunomodulatory effects	Decrease pain score and aphthous wound healing period, promote eye external part treatment, downregulate lipopolysaccharide-induced inflammatory cytokine production and NLRP3 inflammasome expression, potentiate lymphocyte response, phagocytosis and circulating monocyte and macrophage levels	Acemannan, polysaccharides	[75,254,266,318,319,320,321]
Antidiabetic effects	Lower blood glucose levels, reduce body weight, body fat mass and insulin resistance, revert impaired fasting glucose levels and impaired glucose tolerance	Plant extracts	[322,323]
Antihyperlipidemic effects	Reduce atherosclerosis, total serum cholesterol and LDL levels	Plant extracts	[323]
Acquired immune deficiency syndrome (AIDS) treatment	Sooth wound and burn of internal organs, inhibit HIV-1 virus	Mannose-6-phosphate, plant extract	[324]
Dental and oral diseases treatment	Heal aphthous ulcers and reduce pain, plaque and gingivitis	Acemannan	[325,326]