Table 4.

circRNA-miRNA pathway in cancer.

Tumour	Associated circRNA	Target miRNA	Hypothesized miRNA Function	Regulatory Role of circRNA on miRNA	circRNA Expression in Tumor	Potential circRNA Biomarker	Author
Bladder carcinoma	circTCF25	miR-103a-3p/miR-107	Tumor supressor-miR	Negative	↑	na	[181]
Bladder carcinoma	cir-ITCH	miR-17/miR-224	Onco-miR	Negative	↓	prognostic	[182]
Bladder carcinoma	circRNA-Cdr1as	miR-135a	Onco-miR	Negative	↓	na	[183]
Breast carcinoma	circ-ABCB10	miR-1271	Tumor supressor-miR	Negative	↑	na	[184]
Breast carcinoma	circRNA-000911	miR-449a	Onco-miR	Negative	↓	prognostic	[185]
Colorectal carcinoma	hsa_circ_000984	miR-106b	Onco-miR	Positive	↑	na	[186]
Colorectal carcinoma	hsa_circ_001569	miR-145	Tumor supressor-miR	Negative	↑	na	[187]
Colorectal carcinoma	circHIPK3	miR-7	Tumor supressor-miR	Negative	↑	prognostic	[188]
Esophageal carcinoma	cir-ITCH	miR-7/miR-17/miR-214	Onco-miR	Negative	↓	na	[189]
Gastric carcinoma	circPVT1	miR-125 family	Tumor supressor-miR	Negative	↑	prognostic	[190]
Hepatocellular carcinoma	circMTO1	miR-9	Onco-miR	Negative	↓	prognostic	[191]
Hepatocellular carcinoma	circRNA-Cdr1as	miR-7	Tumor supressor-miR	Negative	↑	na	[192]
Lung carcinoma	hsa_circ_0013958	miR-134	Tumor supressor-miR	Negative	↑	diagnostic	[193]
Lung carcinoma	cir-ITCH	miR-7/miR-214	Onco-miR	Negative	↓	na	[194]
Osteosarcoma	circUBAP2	miR-143	Tumor supressor-miR	Negative	↑	prognostic	[195]
Prostate carcinoma	circMYLK	miR-29a	Tumor supressor-miR	Negative	↑	diagnostic/ therapeutic	[180]
Renal carcinoma	circHIAT1	miR-195-5p/miR-29a-3p/miR-29c-3p	Tumor supressor-miR	Positive	↓	therapeutic	[196]

na = not available, all sample used was tissues except * = tissues and plasma, ↓ = decrease, ↑ = increase.