Figure 4.
Resistance and modelled parameters Rb, α, and Cm of brain endothelium grown in either Enriched Media or Minimal Media. Endothelial cells were seeded at 20,000 cells per well on a 96w20idf ECIS array. Time 0 h denotes the time cells were seeded. The dotted vertical line indicates 48 h of cell growth in each respective media type, with a subsequent media change carried out at this time. (A) Resistance at 4000 Hz trace over 120 h of cell growth; (B) Raw capacitance trace over 120 h of cell growth; (C) Modelled parameter, Rb, trace over 120 h of cell growth; (D) Modelled parameter, α, trace over 120 h of cell growth; (E) Modelled parameter, Cm, trace over 120 h of cell growth. Data show the mean ± SD (n = 3 wells) of one independent experiment representative of three experimental repeats. Graphical representations of p values are * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.