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Signaling pathways and morphogens that control lineage specification from hPSCs. hPSCs can be differentiated towards the different lineages by BMP and Activin/Nodal inhibition (Neuroectoderm), Wnt signaling modulation (mesoderm and mesendoderm), and further differentiated to definitive endoderm by Activin A activation to generate pancreatic and hepatic lineage-derived cells. BMP: bone morphogenic protein, FGF: fibroblast growth factor, HGF: hepatoblast growth factor.
