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. 2018 Sep 10;8(9):707. doi: 10.3390/nano8090707

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) A schematic drawing to illustrate in vivo magnetic targeting with intravenous injection; (b) Fluorescent and BF images by Maestro imaging of extracted retinas: untreated retina (left), retina close to an external magnet (middle) and retina opposite to magnet side (right); (c) Quantitative analysis of fluorescence image shown in (b); (d) Light microscopy image showing the Prussian blue iron staining followed by counterstaining with nuclear fast red of targeted eye. Scale bar = 100 µm; (e) Biodistribution of particles in mice after magnetic targeting. Inductively coupled plasma (ICP) quantification of iron in organs collected from three test groups: untreated control mice, injected mice and magnet targeted injected mice; (f) Images of H&E stained organs collected from control and MNPs injected mice 18 days after injection.

(a) A schematic drawing to illustrate in vivo magnetic targeting with intravenous injection; (b) Fluorescent and BF images by Maestro imaging of extracted retinas: untreated retina (left), retina close to an external magnet (middle) and retina opposite to magnet side (right); (c) Quantitative analysis of fluorescence image shown in (b); (d) Light microscopy image showing the Prussian blue iron staining followed by counterstaining with nuclear fast red of targeted eye. Scale bar = 100 µm; (e) Biodistribution of particles in mice after magnetic targeting. Inductively coupled plasma (ICP) quantification of iron in organs collected from three test groups: untreated control mice, injected mice and magnet targeted injected mice; (f) Images of H&E stained organs collected from control and MNPs injected mice 18 days after injection.