Table 3.

The Cochrane Risk of Bias Assessment.

Author (Year)	Selection Bias		Performance Bias	Detection Bias	Attrition Bias	Reporting Bias	Other Bias
	Random Sequence Generation	Allocation Concealment	Blinding of Participants and Personnel	Blinding of Outcome Assessment	Incomplete Outcome Data	Selective Reporting
Chibnall et al. (2005) [29]	Unclear	Unclear	Low	Low	Low, 2 of 25 participants did not complete the RCT	Low	Unclear, very small sample size, 1 care home, support from the manufacturer of the medicine investigated.
Baker et al. (2008) [15]	High	High	High, no attempt to blind	Unclear	Unclear, no information	Moderate, no information on adverse effects	High
Morad et al. (2012) [30]	Low	Unclear	High, no information	High-patients and recovery staff were not blinded.	Unclear, 6/34 and 9/34 were excluded for Protocol violations.	High, per protocol not intention to treat analysis	Unclear, very small sample size, single centre
Hajimaghsoudi et al. (2013) [31]	Low	Unclear, no information	High, open label	High, open label	Unclear, no information	Unclear, missing data due to patient non-compliance	Unclear
Park et al. (2015) [32]	Unclear	Unclear	High, open label	Unclear	Moderate, 10/80 participants lost in each arm. No reasons given.	Low, all adverse events were reported	Unclear