Table 1.
Plasma biochemical characteristics (n = 5) in experimental animals.
| Biochemical Characteristics | Weeks | Normal Diet | HC Diet | ||
|---|---|---|---|---|---|
| IMQ Treatment | IMQ Treatment | ||||
| BUN (mg/dL) | 0 | 28.3 ± 6.0 | 26.3 ± 6.5 | 27.2 ± 7.8 | 26.9 ± 5.2 |
| 6 | 26.2 ± 8.0 | 27.4 ± 8.1 | 26.4 ± 7.4 | 28.4 ± 7.2 | |
| Creatinine (mg/dL) | 0 | 0.8 ± 0.2 | 0.7 ± 0.5 | 0.9 ± 0.4 | 0.8 ± 0.3 |
| 6 | 0.6 ± 0.1 | 0.8 ± 0.2 | 0.7 ± 0.5 | 0.7 ± 0.4 | |
| AST (IU/L) | 0 | 25.7 ± 3.8 | 25.6 ± 2.8 | 26.8 ± 3.4 | 264 ± 4.2 |
| 6 | 26.7 ± 3.2 | 27.4 ± 3.6 | 27.4 ± 2.8 | 28.3 ± 3.4 | |
| ALT (IU/L) | 0 | 35.5 ± 9.1 | 34.4 ± 12.3 | 34.6 ± 8.2 | 35.3 ± 7.6 |
| 6 | 34.8 ± 6.4 | 36.8 ± 10.2 | 34.7 ± 6.4 | 34.8 ± 5.2 | |
| Total-cholesterol (mg/dL) | 0 | 28.6 ± 6.2 | 25.2 ± 3.2 | 26.4 ± 7.0 | 27.3 ± 5.8 |
| 6 | 29.5 ± 7.3 | 27.6 ± 4.8 | 1213.5 ± 174.2 * | 1047.0 ± 198.2 * | |
| TG (mg/dL) | 0 | 16.7 ± 8.3 | 18.2 ± 6.4 | 20.4 ± 2.8 | 19.4 ± 5.8 |
| 6 | 14.8 ± 7.2 | 17.2 ± 5.3 | 92.0 ± 18.4 * | 94.0 ± 17.7 * | |
HC diet, high-cholesterol diet; BUN, blood urea nitrogen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TG, triglyceride; IMQ, imiquimod. Values are mean ± SD. * p < 0.05 compared with 0 week of the same group.