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. 2018 Sep 11;19(9):2707. doi: 10.3390/ijms19092707

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TSPO is expressed in the neurogenic regions of the subventricular zone and the rostral migratory stream (RMS). (A) Strong TSPO immunofluorescence (red) is observed in the subventricular zone adjacent to the ependymal lining of the ventricles, and extends through the RMS to the neurogenic niche of the olfactory bulb. (B) TSPO expression (red) is observed in Nestin+ neural stem/progenitor cells (green) in the subventricular zone (sagittal view). (C) In the RMS, TSPO expression in Nestin+ progenitor cells (green) is also high (sagittal view). (D) TSPO expression (red) also colocalizes with GFAP in neural stem/progenitor cells (green) in the subventricular zone (coronal view), confirming the presence of TSPO in neural stem/progenitor cells. Scale bars = 300 µm for (A), 20 µm for (B–D).