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. 2018 Aug 28;19(9):2543. doi: 10.3390/ijms19092543

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Model of growth regulation by estrogen in breast cancer 1 (GREB1) structure and transcription. The human GREB1 gene is located on 2p25.1. Three upstream estrogen response elements (EREs) located at −21.2, −9.5, and −1.6 kb and one androgen response element (ARE) located at −3.3 kb can modulate GREB1 transcription. The GREB1 gene produces at least three isoforms: GREB1a (NM_014668.3 → NP_055483.2), GREB1b (NM_033090.2 → NP_149081.1), and GREB1c (NM_148903.2 → NP_683701.2), which have alternate 5′ and 3′ UTRs. Splicing after exons 10 and 9 results in short GREB1b and GREB1c isoforms, respectively. The GREB1a protein contains two LXXLL motifs and a superfamily II (SFII) helicase module fused with a glycosyltransferase (TAGT) motif in the C-terminus.