Table 2.
ADME (absorption, distribution, metabolism, excretion) properties and drug-likeness scores of the main components present in the C. olitorius extract.
| Compound Name | BBB a | PPB b | HIA c | Caco-2 d | MDCK e | Drug-Likeness Scores |
|---|---|---|---|---|---|---|
| Chlorogenic acid | 0.034 | 41.96 | 20.43 | 18.72 | 4.51 | 1.29 |
| Quercetin-3-galactoside | 0.032 | 59.16 | 11.78 | 9.44 | 2.49 | 0.89 |
| 3,5-Dicaffeoylquinic acid | 0.035 | 86.06 | 23.12 | 19.32 | 0.04 | 1.05 |
| Quercetin-3-glucoside | 0.032 | 58.16 | 11.78 | 4.49 | 2.21 | 0.91 |
| Quercetin-3-(6-malonylglucoside) | 0.047 | 35.48 | 0.39 | 6.70 | 0.06 | 0.70 |
a blood–brain barrier penetration, b plasma protein binding, c human intestinal absorption, d Caco-2 cell permeability, e MDCK cell permeability.