ß-lactams
|
Ampicillin |
E. coli
|
Laboratory medium |
10-fold increase in antimicrobial activity |
[3] |
Quinolones
|
Ofloxacine, Nalidixic Acid, Norfloxacin |
E. coli
|
Laboratory medium |
10-fold increase in antimicrobial activity. MIC value decreased 10–25% |
[3,4] |
Aminoglycosides
|
Gentamicin |
E. coli
|
Laboratory medium. Animal models |
100-fold increase in antimicrobial activity. MIC value decreased more than 10-fold |
[3,4] |
C. difficile
|
Laboratory medium |
MIC value decreased 4-fold |
[4] |
Tobramycin |
E. coli., P. aeruginosa
|
Laboratory medium |
MIC value decreased 10-fold (E. coli). 3-fold increase in antimicrobial activity (P. aeruginosa) |
[4,23] |
Kanamycin Streptomycin |
E. coli
|
Laboratory medium |
MIC value decreased more than 10-fold |
[4] |
Spectinomycin
|
E. coli
|
Laboratory medium |
MIC value decreased 2-fold |
[4] |
Vancomycin
|
E. coli
|
Laboratory medium. Animal models |
10-fold increase in antimicrobial activity |
[3] |
Chloramphenicol
|
E. coli
|
Laboratory medium |
MIC value decreased 1.5-fold |
[4] |
Ebselen
|
K. pneumoniae, A. baumanni, P. aeruginosa, E. cloacae, E. coli
|
Laboratory medium. Animal models |
10-fold increase in MIC value |
[20] |
Polymixin B
|
E. coli
|
Laboratory medium |
MIC value decreased 5- to 10-fold |
[21,22] |
Rifampicin
|
A. baumannii
|
Laboratory medium |
MIC value decreased 5-10 fold |
[21] |
Tetracycline
|
E. coli (TetR) |
Laboratory medium |
MIC value decreased 2-fold |
[3] |