Table 1.
Clinical characteristics of RA (rheumatoid arthritis) patients and their C/EBPβ/NTT/PBOV1 expression levels in PBMCs (peripheral blood mononuclear cells).
| Basic Information | Initial Lab Data | Initial Disease Activity | RNA Expression at RA Diagnosis | Clinical Parameters at 2-Year Follow-Up | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient No. | Sex | Age | RF (IU/mL) | Anti-CCP (U/mL) | ESR (mm/h) | CRP (mg/dL) | DAS28 | SDAI | C/EBPβ (fold) | NTT (fold) | PBOV1 (fold) | Number of Medications Used in Addition to NSAID | DAS28 |
| 1 | F | 57 | 28.2 | 29 | 44 | 1.15 | 5.53 | 19.7 | 58.69 | 1379.57 | 46,663.28 | 4 (Hydroxychloroquine, Sulfasalazine, Cyclosporine, Prednisolone) | 3.86 |
| 2 | F | 56 | 688 | 2.2 | 18 | 0.02 | 4.22 | 15 | 56.69 | 1314.23 | 52,136.28 | NA | NA |
| 3 | F | 55 | 23.4 | 0.8 | 50 | 4.96 | 5.67 | 12.5 | 25.19 | 1045.52 | 39,786.74 | 3 (Hydroxychloroquine, MTX, Adalimumab) | 1.46 |
| 4 | F | 25 | 52.3 | 76 | 106 | 2.57 | 4.35 | 7.8 | 14.27 | 1541.37 | 27,554.49 | 3 (Hydroxychloroquine, MTX, Sulfasalazine) | 1.13 |
| 5 | F | 57 | <20 | 1.4 | 46 | 3.4 | 4.16 | 16 | 12.51 | 522.76 | 8659.09 | 3 (Hydroxychloroquine, Sulfasalazine, Prednisolone) | 2.36 |
| 6 | F | 66 | 413 | 338 | 53 | 1.81 | 4.92 | 11.2 | 7.75 | 216.77 | 6251.56 | 2 (Hydroxychloroquine, Sulfasalazine) | 2.08 |
| 7 | F | 34 | 79.8 | 121 | 8 | 0.03 | 3.45 | 8 | 5.68 | 114.56 | 4420.519 | 2 (Hydroxychloroquine, MTX) | 1.74 |
| 8 | F | 43 | 20 | 3.5 | 28 | 0.68 | 3.46 | 7.1 | 6.52 | 195.36 | 4299.64 | NA | NA |
| 9 | F | 70 | <20 | 0.7 | 50 | 2.52 | 4.74 | 12.8 | 4.13 | 101.83 | 2033.853 | 0 | 2.67 |
| 10 | F | 50 | 137 | 10 | 25 | 0.25 | 3.78 | 8 | 4.77 | 163.14 | 6038.51 | 2 (Hydroxychloroquine, MTX) | 2.20 |
RNA expressions are shown as folds compared to the median of healthy controls. RF: rheumatoid factor; Anti-CCP: anti-cyclic citrullinated peptide antibody; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; DAS28: disease activity score 28; SDAI: simple disease activity index; NSAID: nonsteroidal anti-inflammatory drug; MTX: methotrexate; NA: not available.