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. 2018 Aug 25;19(9):2526. doi: 10.3390/ijms19092526

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of defect regeneration in mice treated with autologous or allogeneic human mesenchymal stem cells (hMSC). (a) Percentage of human CD45-positive cells in the blood of humanized mice pre-surgery analyzed by flow cytometry. (b) Volume of the regenerate and (c) bone fraction in the regenerate assessed by micro-computed tomography on day 35 after surgery. (d) Analysis of the regenerate composition by histomorphometry on day 35. (e,f) Representative von Kossa-stained sections through the regenerate area of mice treated with autologous (e) and allogeneic (f) hMSC. The data are presented as the mean ± SD, * p ≤ 0.05. In (a) autologous n = 6, allogeneic n = 9. In (b–d) autologous n = 4, allogeneic n = 8.