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. 2018 Sep 13;19(9):2750. doi: 10.3390/ijms19092750

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relative (A) SLC2A1 (GLUT1); (B) SLC2A3 (GLUT3); (C) HIF1A mRNA expression detected after 24, 48, and 72 h in a metformin-treated and untreated ovarian cancer cell line (SKOV-3) cultured in NG and in HG. NG—cells cultured in normoglycemia, NG + M—cells cultured in normoglycemia and treated with metformin, HG—cells cultured in hyperglycemia, HG + M—cells cultured in hyperglycemia and treated with metformin. (*) Statistically significant differences between the cells exposed to metformin in comparison to unexposed cells at the same time points, p < 0.05; (#) statistically significant differences between cells cultured in HG in comparison to those cultured in NG at the same time points p < 0.05; (+) statistically significant differences between metformin-treated cells in HG in comparison to metformin-treated cells cultured in NG at the same time points, p < 0.05.

Relative (A) SLC2A1 (GLUT1); (B) SLC2A3 (GLUT3); (C) HIF1A mRNA expression detected after 24, 48, and 72 h in a metformin-treated and untreated ovarian cancer cell line (SKOV-3) cultured in NG and in HG. NG—cells cultured in normoglycemia, NG + M—cells cultured in normoglycemia and treated with metformin, HG—cells cultured in hyperglycemia, HG + M—cells cultured in hyperglycemia and treated with metformin. (*) Statistically significant differences between the cells exposed to metformin in comparison to unexposed cells at the same time points, p < 0.05; (#) statistically significant differences between cells cultured in HG in comparison to those cultured in NG at the same time points p < 0.05; (+) statistically significant differences between metformin-treated cells in HG in comparison to metformin-treated cells cultured in NG at the same time points, p < 0.05.