. 2018 Sep 15;15(9):2017. doi: 10.3390/ijerph15092017

Table 1.

Interventional studies that describe early goal-directed therapy for sepsis in sub-Saharan Africa.

Study	Design	Bias	Country	Participants	Population	Age	Crude Mortality
Andrews, 2014 [22]	Randomised controlled trial (RCT)	4/5	Zambia	112	Accident and emergency (A & E) with severe sepsis [23]	Intervention (35.2, 1.3) ^α Control (34.8, 1.4) ^α	Intervention: 64.2% (n = 53) Control: 60.7% (n = 56)
Andrews, 2017 [16]	RCT	4/5	Zambia	212	A & E with severe sepsis [23]	Intervention (37.5, 12.9) ^α Control (35.8, 11.9) ^α	Intervention: 48.1% (n = 106) Control: 33.0% (n = 103)
Jacob, 2012 [24]	Prospective Cohort	7/9	Uganda	671	Medical ward with sepsis (study specific criteria)	Intervention (34, 27–40) ^β Observation (34, 28–41) ^β	Intervention: 33.0% (n = 426) Observation: 45.7% (n = 245)

Risk of bias assessments: Newcastle–Ottowa scale and Jadad scale for cohort studies and randomised controlled trials, respectively [20,21]. Age: α = mean and standard deviation (SD); β = median and interquartile range (IQR).