Table 2.

Current cell models used to study the characteristics of salivary glands. Adapted from Nelson et al. [29].

Name	Source	Ability to Achieve Polarity	Amylase Expression	Ability to Secrete Fluid	References
HSG	irradiated human submandibular gland	(+)	(+)	(+)	Shirasuna et al. (1981) [31], Shirasuna et al. (1986) [32]
HSY	human parotid gland adenocarcinoma derived from athymic mice	(+)	(+)	(+)	Yanagawa et al. (1986) [35]
SMIE	rat submandibular gland, immortalized with retrovirus vector	(+)	(−)	(+)	He et al. (1990) [38], He et al. (1998) [39]
RSMT-A5	rat submandibular gland, immortalized by methylcholanthrene	(−)	(−)	(−)	Brown (1973) [40], He et al. (1989) [41]
SMG-C	rat submandibular gland, immortalized by SV40 genome	(+)	Unknown	Unknown	Quissell et al. (1997) [43]
Par-C	rat parotid gland, immortalized by SV40 genome	(+)	(−)	(+)	Quissell et al. (1998) [46]