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. 2018 Aug 29;19(9):2573. doi: 10.3390/ijms19092573

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of HI insult and T4 treatment on cyclic adenosine monophosphate response element-binding protein (CREB) and extracellular signal regulated kinase (ERK) signaling in WM. (A) HI insult increased the levels of phosphorylated ERK1/2, whereas the high dose of T4 significantly attenuated the HI enhancement of phosphorylated ERK1/2 levels in WM. (B) HI had no effect on CREB levels, while T4 treatment significantly decreased the levels of phosphorylated CREB (* p < 0.05; *** p < 0.005).