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. 2018 Sep 10;19(9):2694. doi: 10.3390/ijms19092694

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ad5/35-tk-mediated enhancement of in vitro cytotoxicity in bladder cancer cells. CD46-overexpressing (CD46), CD46-suppressed (shCD46), or control EJ bladder cancer cells (veh) were seeded into 24-well plates and cultured overnight. Subsequently, the cells were either left untransduced or were transduced with Ad5-tk or Ad5/35-tk at the indicated MOIs of 5 and 20. The following day, increasing concentrations of GCV were added and an MTT in vitro proliferation assay was performed five days post-infection. Bladder cancer cells used in this experiment are EJ (A), 5637 (B), J82 (C), T24 (D), and HT-1376 (E). The error bars represent SEM. Statistics: p < 0.05 by two-way ANOVA.

Ad5/35-tk-mediated enhancement of in vitro cytotoxicity in bladder cancer cells. CD46-overexpressing (CD46), CD46-suppressed (shCD46), or control EJ bladder cancer cells (veh) were seeded into 24-well plates and cultured overnight. Subsequently, the cells were either left untransduced or were transduced with Ad5-tk or Ad5/35-tk at the indicated MOIs of 5 and 20. The following day, increasing concentrations of GCV were added and an MTT in vitro proliferation assay was performed five days post-infection. Bladder cancer cells used in this experiment are EJ (A), 5637 (B), J82 (C), T24 (D), and HT-1376 (E). The error bars represent SEM. Statistics: p < 0.05 by two-way ANOVA.