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. 2018 Aug 25;19(9):2515. doi: 10.3390/ijms19092515

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The writer, eraser, and direct reader proteins of N⁶-methyladenosine (m⁶A). m⁶A modification is dynamically regulated by writers (METTL3 or METTL14) and erasers (fat mass and obesity-associated (FTO) or ALKBH5), both of which are localized primarily in the nucleus. In the nucleus, m⁶A can be recognized and directly bound by m⁶A readers YTHDC1, HNRNPA2B1, andIGF2BP1/2/3. In the cytoplasm, m⁶A can be recognized and directly bound by m⁶A readers YTHDF1/2/3, YTHDC2, eIF3, and IGF2BP1/2/3. Recognition and binding of m⁶A by different readers in the nucleus or cytoplasm mediate divergent biological functions. WTAP, Wilms’ tumor 1-associating protein.