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. 2018 Sep 14;8(3):86. doi: 10.3390/bios8030086

Figure 4.

Figure 4

cGMP mediated effects on cell surface receptor expression in HUVEC. (A) CNP-stimulated cGMP accumulation in HUVEC isolates, after 30 min stimulation with 100 nm CNP in the presence of 1 mm IBMX. Data shown are means ± SEM pooled from 6 independent isolates (n = 6), each performed in duplicate (* p = 0.015, significantly different from Basal). (B–D) Effect of 8-bromo-cGMP on IFN-γ mediated ICAM-1 (B), MHC-I (C), and MHC-II (D) expressed as fold increase over MFI of untreated cells expression after 48hr treatment (which ranged from 572 to 819, 1313 to 2012, 176 to 230, for ICAM-1, MHC-I and MHC-II, respectively). n = 3 HUVEC isolates (* p < 0.05, *** p < 0.001, significantly different from IFN-γ alone).