Table 1.

Summary of data on the effect of IL-33/ST2 signaling on development of different cancers.

Type of Cancer	Pro- or Anti-Tumorigenic Effect on Tumor	Model Used	References
Breast	Pro-tumorigenic	Mouse models	[51,52,54,55,56,57]
		Patient tissues	[56,57,58,59,60,61]
Colon	Pro-tumorigenic	Mouse model	[66,67,68,72,73,74]
		Patient tissue and cell lines	[64,65,72,74]
	Anti-tumorigenic	Mouse model and cell lines	[47,75]
Gastric	Pro-tumorigenic	Mouse model	[78,79]
Hepatocellular	Pro-tumorigenic	Patient sera or plasma, resected patient tissues	[80,81,82,83]
Hepatobiliary	Pro-tumorigenic	Mouse model of CCA Patient tissues	[84]
Pancreatic	Pro-tumorigenic	Cell lines, tissues	[87,88]
Lung	Pro-tumorigenic	Patient samples and cell lines	[90,91,92,93,94]
	Anti-tumorigenic	Patient studies	[95,96,97]
		Mouse models	[76,98,99]
Prostate & kidney	Pro-tumorigenic	Mouse Model	[100]
	Anti-tumorigenic	Patient tissue	[99]
Ovarian	Pro-tumorigenic	Patient tissues and human ovarian cell lines	[101]
Uterine	Pro-tumorigenic	Patient sera	[102,103]
Endometrial	Pro-tumorigenic	Patient sera and tissues	[104]
Cervical	Pro-tumorigenic	Patient tissue and in vitro studies	[105]
Head and Neck	Pro-tumorigenic	Organotypic culture and patient tissues	[106]
Brain	Pro-tumorigenic	Patient tissue	[107]
		Rat model of glioma	[108]
Mouth	Pro-tumorigenic	Human tissues	[109,111]
		Mouse model of salivary gland tumor	[110]
	Anti-tumorigenic	Patient tissue immunohistochemistry	[112]
Skin	Pro-tumorigenic	Mouse and human cell lines	[113]
	Anti-tumorigenic	Mouse models and cell lines	[114]
Squamous cell carcinoma	Pro-tumorigenic	Mouse cell lines and model Cell lines and patient tissues	[117,118]
Blood cancers	Pro-tumorigenic	Mouse model and patient biopsies	[119,120]
		Cell lines	[121]
		Patient plasma and tissues	[122,123,124]
Lymphoma	Pro-tumorigenic	Mouse model and patient tissue	[125,130]
Bone cancer pain	Pro-tumorigenic	Mouse model	[131]