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. 2018 Sep 6;19(9):2652. doi: 10.3390/ijms19092652

Figure 6.

Figure 6

Resveratrol and quercetin reduce inflammation in the mouse model of contact hypersensitivity. H&E (hematoxylin and eosin) staining and immunohistochemical detection of CD3 and ICAM-1 in ear sections of sensitized mice 48 h after treatment with the vehicle, without subsequent contact hypersensitivity elicitation (vehicle + no elicit, A1–A3) or with elicitation with DNFB (vehicle + elicit, B1–B3). One hour prior to DNFB elicitation, on the skin site of elicitation (both sides of both ears), selected groups of sensitized mice were topically treated with 4 mM gefitinib (Gefit, E1–E3). Other groups of animals were prepainted with 10 mM resveratrol (Resv, 23 μg/ear side) or quercetin (Querc, 33 μg/ear side) 1 h prior to vehicle (Resv + vehicle + elicit, C1–C3, Querc + vehicle + elicit, D1–D3) or to Gefit (Resv + Gefit + elicit, F1–F3, Querc + Gefit + elicit, G1–G3). All applications were performed by painting 10 μL solutions per each side of each ear. Vehicle, 10% DMSO in absolute ethanol. Magnification: H&E, ×50; CD3 and ICAM-1, ×200. The results are representative of three independent experiments.