WAY 100635 blocked the improvements in social interaction, anxiety and hyperlocomotion instigated by ILPFCDBS in the VPA-exposed offspring. (A) Duration of latency on entering chamber E, the center chamber, and chamber S1 during the three-chamber social interaction test; (B) preference index in the social interaction test; (C) percentage of time spent in the open arms; (D) total distance traveled in the open field test. * p < 0.05 vs. VPA/sham; *** p < 0.05 vs. VPA/sham; #
p < 0.05 vs. VPA/DBS; ##
p < 0.01 vs. VPA/DBS; ###
p < 0.001 vs. VPA/DBS. Sample sizes (n): saline/sham n = 7, VPA/sham n = 9, VPA/DBS n = 5, VPA/DBS/WAY 100635 n = 5.