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. 2018 Sep 19;19(9):2840. doi: 10.3390/ijms19092840

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DBS and 8-OH-DPAT treatment reversed the increased expressions of NMDAR subunit NR2B and the GABA_AR β3 subunit in the VPA-exposed offspring. (A) Representative blots and quantification showing the synapse NMDAR subunit NR2B expression after 8-OH-DPAT treatment in the VPA-exposed offspring. Sample sizes (n): Saline n = 12, VPA n = 9, VPA/8-OH-DPAT n = 5; (B) representative blots and quantification showing the synapse GABA_AR β3 subunit expression after 8-OH-DPAT treatment in the VPA-exposed offspring. Sample sizes (n): Saline n = 4, VPA n = 4, VPA/8-OH-DPAT n = 4; (C) immunoblots and quantification showing the synapse NMDAR subunit NR2B expression after seven days of DBS and after three days of DBS combined with 8-OH-DPAT treatments in the VPA-exposed offspring. Sample sizes (n): VPA n = 14, VPA/DBS n = 12, VPA/DBS/8-OH-DPAT n = 12; (D) western blotting showing the synapse GABA_AR β3 subunit expression after seven days of DBS and after three days of DBS combined with 8-OH-DPAT treatment in the VPA-exposed offspring. Sample sizes (n): VPA n = 8, VPA/DBS n = 6, VPA/DBS/8-OH-DPAT n = 6. * p < 0.05 vs. saline/vehicle; ** p < 0.01 vs. saline/vehicle; * p < 0.05 vs. saline; ** p < 0.01 vs. saline; ** p < 0.01 vs. VPA; *** p < 0.001 vs. VPA; ^## p < 0.01 vs. VPA; ^### p < 0.001 vs. VPA.