Table 2.
Effects of ASEP-P on body weight, immune organ indices, and lymphocyte proliferation in normal mice. ASEP-P (100 or 200 mg/kg) was administered daily for 28 days. CVT-E002™ (100 mg/kg) was used as a positive control (PC). The control group mice were treated with vehicle (normal saline solution). The data are expressed as the means ± standard deviation (n = 10). * p < 0.05, ** p < 0.01 compared with the vehicle-treated control group.
| Group | Body Weight (g) | Immune Organ Indices (mg/g) | Splenocyte Proliferation (%) | |||
|---|---|---|---|---|---|---|
| Initial | Final | Spleen | Thymus | T-Lymphocytes | B-Lymphocytes | |
| Control | 22.00 ± 1.79 | 34.30 ± 3.46 | 0.62 ± 0.06 | 0.33 ± 0.13 | 100.0 ± 14.8 | 100.0 ± 11.8 |
| ASEP-P (100 mg/kg) | 22.13 ± 1.84 | 34.33 ± 3.28 | 0.70 ± 0.07 | 0.38 ± 0.09 | 113.1 ± 18.6 * | 115.7 ± 19.4 * |
| ASEP-P (200 mg/kg) | 21.75 ± 1.63 | 34.25 ± 3.93 | 0.74 ± 0.10 * | 0.41 ± 0.10 | 125.1 ± 11.7 ** | 124.2 ± 20.2 ** |
| PC (100 mg/kg) | 21.94 ± 1.75 | 34.21 ± 2.93 | 0.76 ± 0.07 * | 0.41 ± 0.13 | 124.4 ± 14.1 ** | 123.0 ± 13.8 ** |