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The mechanism of TB diagnosis using a paper-based sensor. If extracted DNA sequences contain IS6110 sequences (specific to Mycobacterium tuberculosis complex), detection oligonucleotide sequences will hybridize with the sequences. If IS6110 sequences are not present, the color of the mixture does not change, and stays red after hybridization with DNA. The color change can be quantified through the analysis of a picture taken via smartphone. Reproduced with permission from [61].
