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. 2018 Aug 28;19(9):2552. doi: 10.3390/ijms19092552

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) 2D interaction diagrams for the binding of EGFR (PDB code 1M17) with gefitinib; (b) the structure of (E)-1-(5-Bromo-2-(4-fluorophenyl)benzofuran-7-yl)-3-(4-methoxyphenyl)prop-2-en-1-one (3i); (c) the structure of E)-1-(5-Bromo-2-(3-fluorophenyl)benzofuran-7-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one (3o). Residues are annotated with their three-letter amino acid code.

(a) 2D interaction diagrams for the binding of EGFR (PDB code 1M17) with gefitinib; (b) the structure of (E)-1-(5-Bromo-2-(4-fluorophenyl)benzofuran-7-yl)-3-(4-methoxyphenyl)prop-2-en-1-one (3i); (c) the structure of E)-1-(5-Bromo-2-(3-fluorophenyl)benzofuran-7-yl)-3-(4-(trifluoromethoxy)phenyl)prop-2-en-1-one (3o). Residues are annotated with their three-letter amino acid code.