Table 1.
Homologies at the osteopontin-c splice junction.
| A | |||||
| Splice Variant | Junction | ||||
| OPNa | SGSSEEKQ LYNKYPDAVATWLNPDPSQKQNLLAPQ NAVSSEETNDFKQ ETLPSKS | ||||
| OPNb | SGSSEEKQ LYNKYPDAVATWLNPDPSQKQNLLAPQ ETLPSKS | ||||
| OPNc | SGSSEEKQ NAVSSEETNDFKQ ETLPSKS | ||||
| B | |||||
| Homo sapiens | Osteopontin-c | DSGSSEEKQNAVSSEETND | Nuclear | ||
| BLASTP | EJP73436.1 | SAR86 cluster bacterium | ribosomal protein L25 | DEGSSEEQQN---SEETSE | |
| XP_016425206.1 | Sinocyclocheilus rhinocerous | G2 and S phase-expressed protein 1 | ESESQEEKQTSVSNEET | ||
| XP_016313011.1 | Sinocyclocheilus anshuiensis | G2 and S phase-expressed protein 1-like | ESESQEEKQTSVSNEET | ||
| WP_035346390.1 | Bacillus hemicellulosilyticus | carbohydrate ABC transporter substrate-binding protein | DS-SNEPSENDVSSEETND | ||
| WP_092544273.1 | Zunongwangia mangrovi | DUF1343 domain-containing protein | SSEKKQDSVNSEET | ||
| XP_016350400.1 | Sinocyclocheilus anshuiensis | protein P200-like | SGSPAERQNPVASEET | ||
| PNY04530.1 | Trifolium pratense | GDSL esterase/lipase | GNSEEKENFVSSSET | ||
| EJP72445.1 | SAR86 cluster bacterium | dihydrolipoyllysine-residue acetyltransferase | EEK-N-VSSEETND | ||
| XP_018304503.1 | Trachymyrmex zeteki | putative inhibitor of apoptosis | SGSS---QNSISSEITND | ||
| XP_010124132.1 | Chlamydotis macqueenii | MAX gene-associated protein | GSSEEKEDSVSSE | + | |
| XP_010079896.1 | Pterocles gutturalis | MAX gene-associated protein | GSSEEKENSVSS | + | |
| ELM | DOC_USP7_MATH_1 | USP7 MATH domain binding motif variant (MDM2 and p53 interactions) | AVSSE | + | |
| MOD_CK2_1 | CK2 phosphorylation site | NAVSSEE | (+) | ||
| MOD_GSK3_1 | GSK3 phosphorylation recognition site | NAVSSEET | (+) | ||
| MOD_CK1_1 | CK1 phosphorylation site | SGSSEEK | (+) | ||
| MOD_CK2_1 | CK2 phosphorylation site | DSGSSEE | (+) | ||
| LIG_TRAF2_1 | Major TRAF2-binding consensus motif | SSEE | |||
| DEG_Nend_UBRbox_2 | N-terminal motif that initiates protein degradation | DS | |||
| MOD_GlcNHglycan | Glycosaminoglycan attachment site | DSGS | |||
(A) Perijunctional sequences for osteopontin-a compared to the splice variants-b and -c. (B) Homologies to the splice junction of osteopontin-c according to BLASTP and to ELM. The top row shows the search sequence. In the last column, + indicates nuclear localization, (+) indicates that the location of the match may be nuclear or cytosolic.