Table 2.
Homologies at the (T/S)EED domain of osteopontin.
| A | ||||
| Motif | Order | |||
| QYPDATDEDI-T | Primate | |||
| QSPDATEEDF-T | Artiodactyla b | |||
| QYPDSTEEDF-T | Carnivora | |||
| QYPDATEEDL-T | Chiroptera | |||
| QVHDVTEEDL-T | Marsupialia | |||
| QGHDAS-DDF-T | Prototheria | |||
| IVHDATEEDDST | Reptilia a | |||
| DSHDVSDEFDST | Reptilia b | |||
| IEDDATAEVG-- | Aves 1 | |||
| IXYDATEEDESA | Aves 4 | |||
| VHSDLLEEDTST | Fish | |||
| B | ||||
| motif | ||||
| (Q/I)(Y/S/V)(P/H/Y)D(A/V)(T/S)EED(L/E)(-/S)T | ||||
| redox reactions | ||||
| WP_010917268.1 | Thermoplasma | radical SAM protein | YPDETDEDI | generates radicals by close proximity of a 4Fe-4S cluster and S-adenosylmethionine |
| WP_077813583.1 | Acetobacter | (2Fe-2S)-binding protein | YPDPTDEDI | Ferredoxins are iron-sulphur proteins that mediate electron transfer |
| WP_101432357.1 | Bifidobacterium | NAD-dependent succinate-semialdehyde dehydrogenase | YPDATDED | oxidoreductase acting on donor aldehyde or oxo group with NAD+ or NADP+ as acceptor |
| WP_089241263.1 | Belliella | OsmC family peroxiredoxin | SPDATEEEF | osmotically induced, preferentially metabolizes organic over inorganic hydrogen peroxide |
| APR84224.1 | Minicystis | Oxidoreductase, short chain dehydrogenase/reductase | PDATEEDF | NAD(P)(H)-dependent oxidoreductase |
| ODM17387.1 | Aspergillus | Delta-1-pyrroline-5-carboxylate dehydrogenase | PDATEEDF | oxidoreductase, acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor |
| nuclear structure/function | ||||
| WP_069109061.1 | Jiangella | helix-turn-helix domain-containing protein | SPDSTEEDF | helix-turn-helix motif, contained in DNA binding proteins that regulate gene expression |
| KYN05282.1 | Cyphomyrmex | X-ray repair cross-complementing protein 5 | PDATDDDIT | single-stranded DNA-dependent ATP-dependent helicase |
| XP_017256983.1 | Daucus | mitotic spindle checkpoint protein BUBR1 | SPKATEEDFT | control of cell division |
| others | ||||
| WP_100323843.1 | Xanthomonadaceae | 3-oxoacyl-ACP synthase III | SPEATEEDF | acyl-transferase that participates in fatty acid biosynthesis |
| WP_019509474.1 | Pleurocapsa | 1-acyl-sn-glycerol-3-phosphate acyltransferase | QYPDATDDQI | converts lysophosphatidic acid into phosphatidic acid by incorporating an acyl moiety |
| WP_056956354.1 | Lactobacillus | aryl-phospho-beta-d-glucosidase | PDATEEDF | catalyzes the hydrolysis of aryl-phospho-beta-d-glucosides |
| WP_101098638.1 | Stenotrophomonas | VacJ family lipoprotein | PDATEDDFT | contributes to virulence, affects outer membrane and contributes to serum resistance |
| WP_018890097.1 | Streptomyces | ABC transporter ATP-binding protein | PDATDEEIT | ATPase activity, coupled to transmembrane movement of substances |
| XP_011594169.1 | Aquila | unconventional myosin-IXb | QSPDATEEE | intracellular movements, binds actin, inhibited by calcium, GTPase activator for RHOA |
| WP_056534355.1 | Bacillus | DUF1836 domain-containing protein | HDVTEEDLT | domain of unknown function |
| WP_072744531.1 | Sporanaerobacter | Stk1 family PASTA domain-containing Ser/Thr kinase | QVHNVTEENL | StkP activation and substrate recognition depend on the PASTA domain |
| XP_011141917.1 | Harpegnathos | UDP-glucuronosyltransferase 2B15 | VHDVTEEKLT | glucuronidation of various xenobiotics and endogenous estrogens and androgens |
| XP_019462595.1 | Lupinus | ubiquitin carboxyl-terminal hydrolase 27 | QVHDVSEED | Deubiquitinase, reduces BCL2L11/BIM ubiquitination and stabilize BCL2L11 |
| XP_020978497.1 | Arachis | glutamate receptor 3.6 | PDATDEEIT | cell surface receptor |
(A) Canonical sequences for the taxonomic subgroups analyzed. (B) Homologies in BLASTP searches. The upper row shows the consensus motif.