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Possible regulatory mechanisms for the expression of TFIIIA-7ZF and HDAg-S. (A) PSTVd directly binds to RPL5 to regulate alternative splicing of TFIIIA, resulting in optimized TFIIIA-7ZF expression and PSTVd replication; (B) The expression of HDAg-S and HDAg-L is regulated through A-to-I RNA editing at a specific site. Hepatitis delta virus (HDV) RNA structure may affect the editing. In addition, HDAg-S itself may also impact the editing efficiency in group 1 HDV.
