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. 2018 Sep 6;19(9):2637. doi: 10.3390/ijms19092637

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of peiminine on (A) the myeloperoxidase (MPO) activity in the mammary gland of LPS-induced mastitis, the levels of (B) tumor necrosis factor alpha (TNF-α), (C) interleukin-6 (IL-6), and (D) interleukin-1β (IL-1β) in the homogenate of the mouse mammary tissues, including the NT group, the LPS group, and the groups treated with peiminine (1, 3, and 5 mg/kg), and the protein levels of (E,F) COX-2 and (E,G) iNOS were measured by western blotting. The data are presented as the mean ± SD (n = 6). The number sign (#) indicates p < 0.0001, which was significantly different from the NT group. The tetrad asterisks (****) indicate p < 0.0001, the triple asterisks (***) indicate p < 0.0005, the double asterisks (**) indicate p < 0.01, and the single asterisk (*) indicates p < 0.05 vs. the LPS group.