Figure 3.

Fermented ginseng sample A showed higher antiviral protective activity against 1.0 LD₅₀ H3N2 influenza viruses. Groups of mice (n = 5, CD8 T cell-deficient, CD8KO) were intranasally (IN) infected with a mixture of 1 LD₅₀ of A/Philippines/82 (H3N2) virus and fermented ginseng sample A or B at different doses (250 and 500 μg). After 14 days of body weight monitoring, the serum sample was collected to detect the levels of IgG and IgG isotypes after the first infection using an ELISA method. The mice that survived from H3N2 virus infection were challenged with homogenous virus (1.5 LD₅₀, H3N2). (A) Body weight change after the first infection (H3N2) and (B) body weight change after the second infection (H3N2). (C) H3N2 specific IgG, (D) IgG1, and (E) IgG2c after the first infection. F.G.A: H3N2 virus + fermented ginseng sample A; F.G.B: H3N2 virus + fermented ginseng sample B; H3N2 only: virus infection without ginseng samples.