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Vincristine in co-treatment with FK506 decreases tumor growth in vivo. A subcutaneous tumor was generated in Sprague-Dawley rats with C6-derived GSCs. Ten days post-inoculation, rats were treated with vehicle (black), FK506 (blue; 2.25 mg/kg/72 h/intravenous), Vc (green; 0.3 mg/kg/72 h/intravenous) or FK506/Vc (red) for seven days. The graph represents tumor volume (in cm3) over a total of 17 days. Graphs represent the mean ± S.D. ** p < 0.01 and *** p < 0.001 versus vehicle. n = 4.
