Table 2.
Effects of different diets on formation of aberrant crypt foci (ACF) in rat colon six weeks after AOM injections (2 × 15 mg/kg) (n = 12).
| Type/Location | Cellulose Only (Control Diet) | Pectin | Cellulose + EGCG | Pectin + EGCG | Cincau Extract | Cincau Leaves |
|---|---|---|---|---|---|---|
| ACF Incidence | 12/12 | 12/12 | 12/12 | 12/12 | 12/12 | 12/12 |
| Total No. ACF | 73.2 ± 12.1 a | 110.7 ± 19.6 b | 64.7 ± 8.5 a | 114.5 ± 14.1 b | 79.7 ± 10.7 ab | 88.8 ± 10.7 ab |
| 1 Crypt | 32.9 ± 5.2 a | 53.6 ± 10.9 b | 31.5 ± 4.5 a | 52.3 ± 5.6 b | 43.4 ± 4.3 ab | 44.5 ± 5.0 ab |
| 2 Crypts | 26.8 ± 4.7 ac | 40.5 ± 6.7 ab | 23.7 ± 3.2 c | 41.3 ± 5.9 b | 23.5 ± 4.6 c | 30.2 ± 4.5 abc |
| 3 Crypts | 8.4 ± 1.7 a | 10.6 ± 1.9 ab | 7.1 ± 1.3 a | 14.5 ± 2.5 b | 7.7 ± 2.1 a | 9.7 ± 1.8 ab |
| <4 Crypts | 68.2 ± 11.2 a | 104.9 ± 18.5 b | 62.3 ± 8.8 a | 108.2 ± 13.0 b | 74.7 ± 9.3 ab | 84.4 ± 9.8 ab |
| ≥4 Crypts | 4.5 ± 1.0 ab | 5.8 ± 1.3 b | 2.4 ± 0.5 a | 6.4 ± 1.5 b | 4.3 ± 1.3 ab | 4.3 ± 0.9 ab |
| Proximal Colon | 1.6 ± 0.6 a | 2.0 ± 0.8 a | 0.6 ± 0.2 a | 3.6 ± 2.7 a | 3.2 ± 1.9 a | 2.4 ± 1.4 a |
| Middle Colon | 38.8 ± 6.4 a | 64.3 ± 14.3 a | 43.0 ± 7.2 a | 63.0 ± 11.3 a | 44.1 ± 9.7 a | 49.8 ± 8.1 a |
| Distal Colon | 32.8 ± 6.7 ac | 44.4 ± 6.5 ab | 21.2 ± 2.9 c | 48.0 ± 3.2 b | 32.4 ± 4.4 ac | 36.4 ± 6.8 ab |
Values are expressed as mean ± SE. Means in the same row with a different superscript are significantly different when the LSD method was applied for post-hoc analysis (p ≤ 0.05). EGCG, 0.1% epigallocatechin-3-gallate.