Table 1.

Comparison of PaCS and sequestosome features.

	PaCS	Sequestosome
Ultrastructure *	Collection of barrel-like particles	Granulofibrillar arrays
Content
(a) Proteasome	Yes	No
(b) Polyubiquitinated proteins	Yes (likely K48-linked)	No
(c) Hsp 70 and 90	Yes	No
(d) P62/SQSTM1	No	Yes
Degradation by autophagy	Possible	Possible
Entering cell blebs and ectosomes	Frequent	Not found
Associated pathology	Clear cell neoplasms	Hepatocellular cancer

* See also Figure 6.