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. 2018 Jun 22;6(3):73. doi: 10.3390/biomedicines6030073

Figure 10.

Figure 10

Tumor outgrowth volume of mice intravenously treated with CA+ESR1 siRNA, CA+BCL-2 siRNA and CA+ESR1+BCL-2 siRNA complexes on a 4T1 induced breast tumor mouse model. Mice were administered twice (three days apart) with 100 µL of CA, CA+ESR1 siRNA, CA+BCL-2 siRNA and CA+ESR1+BCL-2 siRNA complexes. CA+siRNA complexes were formed by mixing 50 mM of a particular siRNA along with 4 μL of 1 M CaCl2 in 100 μL of freshly prepared bicarbonated (44 mM) DMEM media and incubating at 37 °C for 30 min. Six mice per group were used and data was represented as mean±SD. Values were significant with * p < 0.05 compare to the control group.