Table 2.

Effects of animal studies aiming to evaluate the therapeutic potential of exogenous recombinant gelsolin.

Disease	Used Animals	Mechanism of Therapeutic Action of Gelsolin	Ref.
Lung injuries	Mice, rats	decrease of acute inflammatory response, binding of inflammatory mediators, limitation of neutrophil migration, inhibition of neutrophil adhesion to endothelial surface, improvement of pulmonary microvascular functions	[38,83]
Burns and thermal injuries	Mice	decrease of acute neuroinflammatory response, binding of inflammatory mediators, decrease of elevated caspase-3 activity, improvement of peripheral T lymphocyte functions, regulation of oxidative response, shortening of bleeding time	[42,84]
Sepsis	Mice, rats	binding of free circulating actin released from damaged cells, decrease of acute inflammatory response, binding of inflammatory mediators	[85,86]
Pneumonia	Mice	decrease of acute inflammatory response, binding of inflammatory mediators, improvement of bacterial clearance by macrophages via NOS3-dependent mechanism	[87]
Alzheimer’s disease	Mice	decrease of apoptosis, regulation of oxidative response, limitation of Aβ fibrillogenesis and Aβ-induced neurotoxicity	[88,89]
MS/EAE	Mice	decrease of acute neuroinflammatory response, binding of inflammatory mediators, regulation of oxidative response	[35]
Diabetes	Mice	depolymerization of F-actin	[36]

Abbreviations: MS: multiple sclerosis; EAE: experimental autoimmune encephalomyelitis.