Table 1.

Relevant studies on resveratrol supplementation as a reprogramming strategy in animal models of fetal programming associated with metabolic syndrome-related phenotypes.

Dose and Period of Resveratrol Supplementation	Animal Models	Gender/Species	Group Size	Age at Evaluation	Beneficial Effects on Offspring	Ref.
0.37% w/w resveratrol in diet between 3 months before the breeding and gestational day 130	Maternal Western-style diet	Japanese macaques	N = 6	Gestational day 130	Restored the loss of fetal islet vascularity	[44]
0.37% w/w resveratrol in diet between 3 months before the breeding and gestational day 130	Maternal Western-style diet	Japanese macaques	N = 6	Gestational day 130	Reduced lipid deposition in the fetal liver	[45]
Resveratrol (50 mg/L) in drinking water during pregnancy and lactation	Maternal high-fat diet	Male and female Wistar rats	N = 4–6	3 weeks	Attenuated hyperglycemia, obesity and hyperlipidemia	[46]
Resveratrol (4 g/kg of diet) between 3–12 weeks of age	Prenatal hypoxia and postnatal high-fat diet	Male SD rats	N = 6	12 weeks	Prevented hypertension	[47]
Resveratrol (4 g/kg of diet) between 3–12 weeks of age	Prenatal hypoxia and postnatal high-fat diet	Male and female SD rats	N = 10	12 weeks	Attenuated insulin resistance in males	[48]
Resveratrol (4 g/kg of diet) between 3–12 weeks of age	Prenatal hypoxia and postnatal high-fat diet	Male SD rats	N = 6	12 weeks	Attenuated insulin resistance and hyperlipidemia	[49]
Resveratrol (50 mg/L) in drinking water from weaning to three months of age	Maternal plus post-weaning high-fructose diet	Male SD rats	N = 8	12 weeks	Prevented hypertension	[50]
0.2% w/w resveratrol in diet during pregnancy and lactation	Maternal plus post-weaning high-fat diet	Male C57BL/6 J mice	N = 10	14 weeks	Prevented obesity and hyperlipidemia	[51]
0.5% resveratrol in drinking water between 2 and 4 months of age	Maternal plus post-weaning high-fat diet	Male SD rats	N = 8–10	16 weeks	Prevented hypertension	[52]
Resveratrol (20 mg/kg/day) via oral gavage during pregnancy	Maternal low protein diet	Male and female Wistar rats	N = 7–14	16 weeks	Attenuated obesity and insulin resistance	[53]

Studies tabulated according to offspring age at evaluation; SD rats = Sprague-Dawley rats.