Table 3.
Number of differentially expressed transcripts in comparisons of the experiment groups of the 19th DLR parabolic flight campaign. Differential expression is defined as t-test p-value < 0.05; fold change (FC) ≤ −1.3 or ≥ +1.3. If the ratio is <1, FC is calculated as the negative reciprocal of the ratio. The term “transcripts” refers to 188 oxidative stress-related transcripts, representing 86 genes. For the abbreviations of the experiment group names see Table 1.
Hypergravity-Sensitive Transcripts | ||||
Differentially expressed in BL-PFC hyp-g vs. H/W 1g GC (TEXUS-49-analogous) | Average FC of BL-PFC hyp-g vs. H/W 1g GC | Min/Max FC of BL-PFC hyp-g vs. H/W 1g GC | ||
Differentially Expressed Transcripts | up-regulated | 23 | 2.088 | 3.042 |
down-regulated | 20 | −1.770 | −2.505 | |
total number | 43 | |||
Hypergravity-Sensitive Transcripts, 1g IF-Controlled | ||||
Differentially expressed in BL-PFC hyp-g vs. 1g IF, but not differentially expressed in 1g IF vs. H/W 1g GC | Average FC of BL-PFC hyp-g vs. 1g IF | Min/Max FC of BL-PFC hyp-g vs. 1g IF | ||
Differentially Expressed Transcripts | up-regulated | 19 | 1.727 | 2.184 |
down-regulated | 16 | −1.590 | −2.014 | |
total number | 35 | |||
Microgravity-Sensitive Transcripts, BL-Controlled | ||||
Differentially expressed in µg vs. BL-PFC hyp-g, but not differentially expressed in the same direction in BL-PFC hyp-g vs. H/W 1g GC (TEXUS-49-analogous) | Average FC of µg vs. BL-PFC hyp-g | Min/Max FC of µg vs. BL-PFC hyp-g | ||
Differentially expressed transcripts | up-regulated | 2 | 1.347 | 1.356 |
down-regulated | 1 | −1.495 | −1.495 | |
total number | 3 | |||
Microgravity-Sensitive Transcripts, BL and 1g IF-Controlled | ||||
Differentially expressed in µg vs. BL-PFC hyp-g, but not differentially expressed in 1g IF vs. H/W 1g GC or in the same direction in BL-PFC hyp-g vs. 1g IF | Average FC µg vs. BL-PFC hyp-g | Min/Max µg vs. BL-PFC hyp-g | ||
Differentially expressed transcripts | up-regulated | 1 | 1.338 | 1.338 |
down-regulated | 1 | −1.495 | −1.495 | |
total number | 2 |