Figure 4.

Long-term adenovirus-mediated expression of an active form of AMPK in the liver reduces hepatic lipid accumulation. Ten-week-old male C57BL/6J mice received injections of Ad GFP or Ad AMPK-CA. Fed mice were studied on day 8 after adenovirus administration. (A) Liver triglyceride content and (B) liver cholesterol content (n = 9–10). Data are means ± SEM. * p < 0.05, ** p < 0.01 versus Ad GFP-infected mice by unpaired two-tailed Student’s t-test; (C) Representative images of transmission electron microscopy showing the ultrastructure change in Ad GFP and Ad AMPK-CA livers. Scale bar: 10 µm. Black arrowheads in insets depict lipid droplets.