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. 2018 Sep 13;19(9):2745. doi: 10.3390/ijms19092745

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Target mining for TCM-caused oxidative hepatotoxicity by network pharmacology and bioinformatics enrichment analysis. (A) Scatter plot of enriched KEGG pathways statistics. The gene ratio illustrates the significantly expressed gene number to the total gene number in a certain pathway. (B) Identification of TCM-modulated targets for oxidative liver injury by network pharmacology. (C) GO analysis on the involvement of principal biological process. (*): −log10 (p) > 1.3; (**): −log10 (p) > 2, and (***): −log10 (p) > 3 versus background genes.