ALD |
alcoholic liver disease |
ALP |
alkaline phosphatase |
ALS |
amyotrophic lateral sclerosis |
ALT |
alanine transaminase |
AST |
aspartate aminotransferase |
ATF6 |
activating transcription factor 6 |
ATP |
adenosine triphosphate |
CAT |
catalase |
CHOP |
C/EBP homologous protein |
CytC |
cytochrome C |
CYP2C19 |
cytochrome P2C19 |
CYP2E1 |
cytochrome P2E1 |
CYP3A |
cytochrome P3A |
CYP3A4 |
cytochrome P3A4 |
CYP450 |
cytochrome P450 |
DAVID |
database for annotation, visualization and integrated discovery |
DBil |
direct bilirubin |
eNOS |
endothelial NO synthase |
ER |
endoplasmic reticulum |
GPx |
glutathione peroxidase |
GRP78 |
glucose regulated protein |
GSH |
glutathione |
GST |
glutathione S-transferase |
HCC |
hepatocellular carcinoma |
HCV |
hepatitis C virus |
HILI |
herb-induced liver injury |
IBil |
indirect bilirubin |
IL-6 |
interleukin 6 |
IL-12 |
interleukin-12 |
IL-14 |
interleukin-14 |
IRE1 |
inositol-requiring enzyme 1 |
iNOS |
inducible nitric oxide synthase |
JNK |
c-Jun N-terminal kinases |
Keap1 |
Kelch-like ECH-associated protein-1 |
KEGG |
Kyoto encyclopedia of genes and genomes |
KOBAS |
KEGG orthology-based annotation system |
LDH |
lactate dehydrogenase |
LPC |
lysophosphatidylcholine |
LPS |
lipopolysaccharide |
MDA |
malondialdehyde |
NA(D)PH |
nicotinamide adenine dinucleotide phosphate oxidase |
NAFLD |
non-alcoholic fatty liver disease |
NO |
nitric oxide |
NOS |
nitric oxide synthase |
NQO1 |
NAD(P)H dehydrogenase, quinone 1 |
Nrf1 |
nuclear respiratory factor 1 |
Nrf2 |
nuclear factor (erythroid-derived 2)-like 2 |
MPT |
mitochondrial permeability transition |
MRP2 |
multidrug resistance-associated protein 2 |
MRP4 |
multidrug resistance protein 4 |
OATP2 |
organic anion transporting polypeptide 2 |
p38 MAPK |
p38 mitogen-activated protein kinase |
p-JNK |
phospho-c-Jun N-terminal kinase |
PERK |
pancreatic ER kinase |
PKC |
protein kinase C |
PLA2 |
phospholipase A2 |
PPAR-α |
peroxisome proliferator activated receptor α |
PPAR-γ |
peroxisome proliferator-activated receptor-γ |
RNS |
reactive nitrogen species |
ROS |
reactive oxygen species |
RUCAM |
Roussel Uclaf Causality Assessment Method |
SOD |
superoxide dismutases |
TBil |
total bilirubin |
TGF-β |
transforming growth factor- β |
TNF |
tumor necrosis factor |
UGT1A1 |
uridine diphosphate glucuronosyltransferase 1A1 |
4-HNE |
4-hydroxynonenal |