Figure 1.

Schematic of fibril made of collagen molecules showing locations for mineral component. Not shown are minerals in the long thing pore zones between collagen molecules, since these only seem to become populated after many months to years in the body [37]. The nanophase bone substitute described in the current manuscript seeks to duplicate mineralization in the 40 nm long gap zones within the fibril. While the larger interfibrillar mineral deposits may also exist, these are not expected to contribute significantly to the behavior of osteoclasts upon material resorption.