Table 1.

Characteristics of the single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations and their associations with AD.

Exposure	SNP	Chr	Nearby Gene	EA *	EAF	Associations with Exposure			Associations with AD
						β †	SE	p	β ‡	SE	p
S-PTH	rs6127099	20	CYP24A1	T	0.34	0.07	0.003	2.4 × 10−72	0.028	0.019	0.155
S-PTH	rs4074995	5	RGS14	G	0.71	0.03	0.003	3.3 × 10−23	0.012	0.018	0.482
S-PTH	rs219779	21	CLDN14	G	0.75	0.04	0.003	8.9 × 10−22	0.023	0.018	0.202
S-PTH	rs4443100	22	RTDR1	G	0.32	0.02	0.003	4.1 × 10−11	0.005	0.017	0.773
S-PTH	rs73186030	3	CASR	T	0.14	0.03	0.004	1.2 × 10−9	−0.032	0.022	0.151
S-25OHD	rs3755967	4	GC	C	0.72	0.089	0.002	4.74 × 10−343	−0.036	0.017	0.034
S-25OHD	rs117913124	11	CYP2R1	G	0.975	0.430 #	0.020	1.50 × 10−88	−0.057	0.065	0.378
S-25OHD	rs12785878	11	DHCR7	T	0.75	0.036	0.002	3.80 × 10−62	−0.022	0.018	0.208
S-25OHD	rs10741657	11	CYP2R1	A	0.40	0.031	0.002	2.05 × 10−46	−0.011	0.016	0.492
S-25OHD	rs17216707	20	CYP24A1	T	0.79	0.026	0.003	8.14 × 10−23	−0.045	0.022	0.038
S-25OHD	rs10745742 §	12	AMDHD1	T	0.40	0.017	0.002	1.88 × 10−14	−0.006	0.016	0.691
S-25OHD	rs8018720	14	SEC23A	G	0.18	0.017	0.003	4.72 × 10−9	−0.012	0.021	0.584

Abbreviations: Chr, chromosome; EA, effect allele; EAF, effect allele frequency; SE, standard error. * Allele associated with higher concentrations of the exposure. ^† β coefficients of the exposure-increasing allele on natural log-transformed concentrations of S-PTH (obtained from Robinson-Cohen et al. [18]) and S-25OHD (obtained from Jiang et al. [19]), if not otherwise indicated. ^‡ β coefficients of the exposure-increasing allele on log odds ratio of AD (obtained from Lambert et al. [21]). ^§ SNP rs10745742 was not available in the dataset for AD. Therefore, rs1968487 was used as proxy (r² between these two SNPs = 1.0). ^# β coefficient of the exposure-increasing allele on standard deviations of the standardized log-transformed S-25OHD concentrations (obtained from Manousaki et al. [20]).