Table 1.
Exposure | SNP | Chr | Nearby Gene | EA * | EAF | Associations with Exposure | Associations with AD | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
β † | SE | p | β ‡ | SE | p | ||||||
S-PTH | rs6127099 | 20 | CYP24A1 | T | 0.34 | 0.07 | 0.003 | 2.4 × 10−72 | 0.028 | 0.019 | 0.155 |
S-PTH | rs4074995 | 5 | RGS14 | G | 0.71 | 0.03 | 0.003 | 3.3 × 10−23 | 0.012 | 0.018 | 0.482 |
S-PTH | rs219779 | 21 | CLDN14 | G | 0.75 | 0.04 | 0.003 | 8.9 × 10−22 | 0.023 | 0.018 | 0.202 |
S-PTH | rs4443100 | 22 | RTDR1 | G | 0.32 | 0.02 | 0.003 | 4.1 × 10−11 | 0.005 | 0.017 | 0.773 |
S-PTH | rs73186030 | 3 | CASR | T | 0.14 | 0.03 | 0.004 | 1.2 × 10−9 | −0.032 | 0.022 | 0.151 |
S-25OHD | rs3755967 | 4 | GC | C | 0.72 | 0.089 | 0.002 | 4.74 × 10−343 | −0.036 | 0.017 | 0.034 |
S-25OHD | rs117913124 | 11 | CYP2R1 | G | 0.975 | 0.430 # | 0.020 | 1.50 × 10−88 | −0.057 | 0.065 | 0.378 |
S-25OHD | rs12785878 | 11 | DHCR7 | T | 0.75 | 0.036 | 0.002 | 3.80 × 10−62 | −0.022 | 0.018 | 0.208 |
S-25OHD | rs10741657 | 11 | CYP2R1 | A | 0.40 | 0.031 | 0.002 | 2.05 × 10−46 | −0.011 | 0.016 | 0.492 |
S-25OHD | rs17216707 | 20 | CYP24A1 | T | 0.79 | 0.026 | 0.003 | 8.14 × 10−23 | −0.045 | 0.022 | 0.038 |
S-25OHD | rs10745742 § | 12 | AMDHD1 | T | 0.40 | 0.017 | 0.002 | 1.88 × 10−14 | −0.006 | 0.016 | 0.691 |
S-25OHD | rs8018720 | 14 | SEC23A | G | 0.18 | 0.017 | 0.003 | 4.72 × 10−9 | −0.012 | 0.021 | 0.584 |
Abbreviations: Chr, chromosome; EA, effect allele; EAF, effect allele frequency; SE, standard error. * Allele associated with higher concentrations of the exposure. † β coefficients of the exposure-increasing allele on natural log-transformed concentrations of S-PTH (obtained from Robinson-Cohen et al. [18]) and S-25OHD (obtained from Jiang et al. [19]), if not otherwise indicated. ‡ β coefficients of the exposure-increasing allele on log odds ratio of AD (obtained from Lambert et al. [21]). § SNP rs10745742 was not available in the dataset for AD. Therefore, rs1968487 was used as proxy (r2 between these two SNPs = 1.0). # β coefficient of the exposure-increasing allele on standard deviations of the standardized log-transformed S-25OHD concentrations (obtained from Manousaki et al. [20]).