Table 3.
Regression coefficients (β), 95 CI and p values for serum exposure concentrations as predictor for serum concentrations of reproductive hormones after adjustment for age, body mass index (BMI) groups, current smoking, time of sampling (not for luteinizing hormone (LH) and follicle-stimulating hormone (FSH)).
| ∑PCB | PFOA | PFOS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| β | 95 CI | p † | β | 95 CI | p † | β | 95 CI | p † | |
| FSH (IU/L) | 0.01 | (−0.06–0.09) | 0.77 | 0.32 | (−0.19–0.83) | 0.22 | 0.23 | (−0.25–0.72) | 0.34 |
| Inhibin B (pg/mL) | 0.05 | (−0.04–0.14) | 0.27 | 0.07 | (−0.56–0.69) | 0.83 | 0.09 | (−0.51–0.69) | 0.77 |
| Inhibin B/FSH | 0.04 | (−0.11–0.19) | 0.61 | −0.09 | (−0.54–0.36) | 0.69 | −0.08 | (−0.51–0.35) | 0.72 |
| LH (IU/L) | 0.06 | (0.01–0.11) | 0.02 | −0.11 | (−0.46–0.24) | 0.54 | 0.35 | (0.02–0.68) | 0.04 |
| T (nmol/L) | 0.04 | (0.004–0.08) | 0.03 | −0.11 | (−0.39–0.16) | 0.42 | 0.11 | (−0.16–0.38) | 0.41 |
| FT (pmol/L) | 0.02 | (−0.02–0.07) | 0.24 | −0.28 | (−0.56–0.002) | 0.05 | −0.03 | (−0.30–0.25) | 0.85 |
| Estradiol (nmol/L) | 0.00 | (−0.04–0.03) | 0.94 | −0.01 | (−0.25–0.23) | 0.93 | 0.07 | (−0.15–0.30) | 0.52 |
| SHBG nmol/L | 0.05 | (0.004–0.09) | 0.03 | 0.23 | (−0.08–0.53) | 0.14 | 0.31 | (0.02–0.60) | 0.04 |
| T/LH | −0.02 | (−0.08–0.04) | 0.55 | 0.00 | (−0.19–0.19) | 1.00 | −0.02 | (−0.30–0.06) | 0.21 |
| FT/LH | −0.04 | (−0.10–0.03) | 0.23 | −0.07 | (−0.26–0.12) | 0.46 | −0.18 | (−0.36–0.01) | 0.06 |
| T/estradiol | 0.05 | (0.01–0.08) | 0.01 | −0.05 | (−0.15–0.06) | 0.41 | 0.02 | (−0.09–0.12) | 0.78 |
| FT/estradiol | 0.03 | (−0.01–0.06) | 0.12 | −0.12 | (−0.21–0.02) | 0.02 | −0.05 | (−0.14–0.62) | 0.35 |
Abbreviation: PCB, polychlorinated biphenyls; ∑PCB = (PCB 138 + PCB 153 + PCB 180) × 2; FSH, follicle-stimulating hormone; LH, luteinizing hormone; SHBG, sex hormone-binding globulin; T, testosterone; FT, free testosterone. All parameters are log transformed. † Significant at 0.05 level (bold text indicates significance).