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. 2018 Aug 16;6(3):65. doi: 10.3390/medsci6030065

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Differentiation of DFMO-treated human OS cells. Effect on the early differentiation marker (A) Alkaline phosphatase (Alk Phos) and late differentiation markers (B) osteopontin (OPN) and (C) collagen, type 1, alpha 1 (Col1a1), after six days of exposure to 5 mM DFMO. All cell lines showed increased levels of OPN, and MG-63 and U-2 OS displayed increased expression of Col1a1, demonstrating terminal osteogenic differentiation. Fold changes in protein levels (indicated below each blot) represent the average of quantified Western blot images from three independent experiments (N = 3).