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. 2018 Sep 19;19(9):2844. doi: 10.3390/ijms19092844

Figure 1.

Figure 1

Andrographolide (Andro) protected PC12 cells from amyloid beta (Aβ)1–42 neurotoxicity. (A) The chemical structure of Andro. Cells were cultured with different concentration of Aβ1–42 (0, 10, 15, and 20 µM); (B) or Andro (6.25, 12.5, 25, and 50 µM); (C) for 24 h, respectively; (D) Cells were co-treated with 10 µM of Aβ1–42 and Andro (5, 10, 15, 20, and 25 µM) for 24 h; (E,F) Cells were pre-treated with Andro (20 μM) for 6, 3, 1, and 0 h and then incubated with 10 μM of Aβ1–42 for a further 24 h, cells were incubated with 10 μM of Aβ1–42 for 1 h, and then co-treated with Andro (20 μM) for 24 h, and the cell ability was detected by methyl thiazolyl tetrazolium (MTT) assay (n = 3). * p < 0.05, ** p < 0.01, versus the control; # p < 0.05, ## p < 0.01 versus Aβ1–42 group was considered statistically significant differences.